12 Modifiable Risk Factors Linked to 40% of World’s Dementia Cases
A recent report by the Lancet Commission on Dementia Prevention, Intervention and Care linked 12 Risk Factors to 40% of the world’s dementia cases. Three – excessive alcohol intake (including any history of passing out with ETOH), traumatic brain injury (TBI) and pollution were recently added to the original nine which were depression; not completing secondary education, hypertension; obesity; hearing loss; smoking; depression; physical inactivity, social isolation; and diabetes. Interestingly, in a study published in the journal Neurology, treatment with a SSRI antidepressant escitalopram lowered amyloid-beta-42 (AB42) levels in the cerebrospinal fluid, suggesting a potential role for these drugs in the prevention of Alzheimer’s disease.
Recommendations to help prevent risk for dementia include:
Getting treated for depressive illness
Aim to maintain systolic blood pressure of 130mmHg or less in midlife from around age 40 years
Encourage use of hearing aids for hearing loss, and reduce hearing loss by protecting ears from high noise levels
Reduce exposure to second-hand tobacco smoke
Prevent head injury, particularly by targeting high-risk occupations
Prevent alcohol misuse and limit drinking to less than 21 units per week in males and 15 in females
Stop smoking and support individual to stop smoking
Lead an active life into midlife and possibly later life